AustralieFrV1, Main, Exploration, bibRecord, 007D64

TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors

Identifieur interne : 007D64 ( Main/Exploration ); précédent : 007D63; suivant : 007D65

TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors

Auteurs : F. P. Valente [France] ; C. Tan [Australie] ; M. Phipps [Malaisie] ; C. S. Witt [Australie] ; G. Kaur [Inde] ; I. Gut [France] ; R. Allcock [Australie] ; P. Price [Australie]

Source :

Tissue Antigens [ 0001-2815 ] ; 2009-07.

RBID : ISTEX:9AC92356C5E27B70DCE4C855B3E42CFF5D6F523E

English descriptors

Abstract

Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We have defined TNF block haplotypes in Asian, European and Australian Aboriginal donors and shown conservation of TNF block haplotypes in geographically distinct populations, consistent with a common evolutionary origin. Here we show that most TNF block haplotypes do not align with a single MHC AH and associations often vary with ethnicity. This suggests more recent recombination events between the TNF block and the HLA alleles.

Url:

https://api.istex.fr/document/9AC92356C5E27B70DCE4C855B3E42CFF5D6F523E/fulltext/pdf

DOI: 10.1111/j.1399-0039.2009.01258.x

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 007D64

Le document en format XML

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<author><name sortKey="Phipps, M" sort="Phipps, M" uniqKey="Phipps M" first="M." last="Phipps">M. Phipps</name>
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<term>Northern india</term>
<term>Polymorphism</term>
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<front><div type="abstract" xml:lang="en">Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We have defined TNF block haplotypes in Asian, European and Australian Aboriginal donors and shown conservation of TNF block haplotypes in geographically distinct populations, consistent with a common evolutionary origin. Here we show that most TNF block haplotypes do not align with a single MHC AH and associations often vary with ethnicity. This suggests more recent recombination events between the TNF block and the HLA alleles.</div>
</front>
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TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors

TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri